Specialista in Oftalmologia 

Prof.ssa Maria Vadalá

Specialista in malattie della retina

Ha sviluppato competenze specialistiche in retina medica nell’ambito delle distrofie retiniche e della patologia retinocoroideale di tipo degenerativo, vascolare, tumorale ed infiammatorio, sia diagnostiche che terapeutiche, nonchè in riabilitazione visiva: ha una attività clinica di ambulatorio e di sala operatoria dal 1993, ad oggi senza soluzione di continuo. Dal 2005, come dirigente medico di I livello presso l’UOC di Oculistica dell’AOUP Paolo Giaccone di Palermo, svolge il ruolo di responsabile del Servizio di Retina Medica. Ha competenze specialistiche nella chirurgia della cataratta e degli annessi.

E’ “Fellow of European Board of Ophthalmology” (FEBO), titolo conferito da European Board of Ophthalmology nel 2018.

E’ investigatore di progetti di ricerca e studi clinici nazionali ed internazionali, autore di pubblicazioni scientifiche, relatore a corsi e congressi nazionali ed internazionali, docente presso l’Università di Palermo sia con attività didattica frontale che come tutor nei corsi di laurea di Medicina e Chirurgia, di Ortottica ed assistenza in oftalmologia, di Scienze delle Riabilitazioni, dei corsi di Specializzazione in Oftalmologia e di Neuropsichiatria infantile.

Nel 1997 ha frequentato il Servizio di Oftalmologia dell’Ospedale Pitié-Salpètrière di Parigi (Francia) diretto dal Prof. Phuc Le Hoang, con principale attenzione alla diagnostica ed alla terapia della patologia infiammatoria del segmento posteriore dell’occhio.

 

Attività scientifica (pubblicazioni dal 2015)

  1. Midena E, Polo C, Frizziero L, Marini MG, Lattanzio R, Vadalà M, Pilotto E, Varano M. The Narrative Medicine Approach in the Treatment of Diabetic Macular Edema: An Italian Experience. Int J Environ Res Public Health. 2022; 19(15):9367. https://doi.org/10.3390/ijerph19159367
  2. Nicolò M, Ciucci F, Nardi M, Parolini B, Russo A, Scupola A, Torregrossa S, Vadalà M; PERSEUS-IT study investigators. PERSEUS-IT 24-month analysis: a prospective observational study to assess the effectiveness of intravitreal aflibercept in routine clinical practice in Italy in patients with neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2022 May 5. doi: 10.1007/s00417-022-05679-6. Epub ahead of print. PMID: 35511286.
  3. Del Pinto R, Mulè G, Vadalà M, Carollo C, Cottone S, Agabiti Rosei C, De Ciuceis C, Rizzoni D, Ferri C, Muiesan ML. Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies. Nutrients. 2022 May 25;14(11):2200. doi: 10.3390/nu14112200. PMID: 35683999; PMCID: PMC9182467.
  4. Bonfiglio V, Rejdak R, Nowomiejska K, Zweifel SA, Justus Wiest MR, Romano GL, Bucolo C, Gozzo L, Castellino N, Patane C, Pizzo C, Reibaldi M, Russo A, Longo A, Fallico M, Macchi I, Vadalà M, Avitabile T, Costagliola C, Jonak K, Toro MD. Efficacy and Safety of Subthreshold Micropulse Yellow Laser for Persistent Diabetic Macular Edema After Vitrectomy: A Pilot Study. Front Pharmacol. 2022 Apr 6;13:832448. doi: 10.3389/fphar.2022.832448. PMID: 35462889; PMCID: PMC9019565.
  5. Vadalà M, Castellucci M, Guarrasi G, Cillino G, Bonfiglio VME, Casuccio A, Cillino S. Polypoidal choroidal vasculopathy in pachychoroid: combined treatment with photodynamic therapy and aflibercept. Int Ophthalmol. 2022 Feb;42(2):601-610. doi: 10.1007/s10792-021-02032-4. Epub 2022 Jan 16. PMID: 35034223.
  6. Scondotto G, Sultana J, Vadalà M, Avitabile T, Cillino S, Foti SS, Labbate L, Longo A, Mirabelli E, Puzo MR, Rapisarda C, Ibanez Toro P, Trombetta CJ, Trifirò G, Virgili G; for ITACA (Intravitreal Therapy Administrative and Clinical Accrue) Network. Assessment of intravitreal anti-VEGF drugs and dexamethasone for retinal diseases in real world setting: A multi-centre prospective study from Southern Italy. Eur J Ophthalmol. 2022 Jan 25:11206721211073402. doi: 10.1177/11206721211073402. Epub ahead of print. PMID: 35075918.
  7. Bonfiglio V, Ortisi E, Nebbioso M, Reibaldi M, Lupidi M, Russo A, Fallico M, Scollo D, Macchi I, Pizzo A, Panebianco R, Patanè C, Vadalà M, Toro MD, Rejdak R, Nowomiejska K, Avitabile T, Longo A. Optical coherence tomography angiography evaluation of peripapillary microvascular changes after rhegmatogenous retinal detachment repair. Retina. 2021 Dec 1;41(12):2540-2548. doi: 10.1097/IAE.0000000000003253. PMID: 34851885.
  8. Bonfiglio V, Reibaldi M, Macchi I, Fallico M, Pizzo C, Patane C, Russo A, Longo A, Pizzo A, Cillino G, Cillino S, Vadalà M, Rinaldi M, Rejdak R, Nowomiejska K, Toro MD, Avitabile T, Ortisi E. Preoperative, Intraoperative and Postoperative Corticosteroid Use as an Adjunctive Treatment for Rhegmatogenous Retinal Detachment. J Clin Med. 2020 May 21;9(5):1556. doi: 10.3390/jcm9051556. PMID: 32455658; PMCID: PMC7290919.
  9. Scalia F, Barone R, Rappa F, Marino Gammazza A, Lo Celso F, Lo Bosco G, Barone G, Antona V, Vadalà M, Vitale AM, Mangano GD, Amato D, Sentiero G, Conway de Macario E, Macario A JL, Giuffrè M, Cappello F. Muscle histopathological and molecular abnormalities in a patient with the CCT5 c.670C>G p.(Leu224Val) mutation predicted to affect the apical domain of the chaperonin subunit. Frontiers in Molecular Biosciences,2022, 9, 887336
  10. Vadalà M, Trapani VS, Amato M, Bongiovanni G, Alaimo F, Cillino S, Bonfiglio VME. Intraoperative dexamethasone intravitreal implant in diabetic macular edema patients undergoing phacoemulsification: The CataDex study. Eur J Ophthalmol. 2021 Dec 8:11206721211062037. doi: 10.1177/11206721211062037. Epub ahead of print. PMID: 34878320.
  11. Staurenghi G, Bandello F, Viola F, Varano M, Barbati G, Peruzzi E, Bassanini S, Biancotto C, Fenicia V, Furino C, Vadalà M, Reibaldi M, Vujosevic S, Ricci F; EAGLE study investigators. Effectiveness of anti-vascular endothelial growth factors in neovascular age-related macular degeneration and variables associated with visual acuity outcomes: Results from the EAGLE study. PLoS One. 2021 Sep 1;16(9):e0256461. doi: 10.1371/journal.pone.0256461. PMID: 34469431; PMCID: PMC8409622.
  12. Cimino L, Neri P, Miserocchi E, Paroli MP, Vannozzi L, Mastropasqua L, Gagliano C, Vadalà M, Figus M, Florio FR, Iaccheri B, Mora P, Fossarello M, Balestrieri P, Gualberti G, Marando F, Accorinti M. Non-infectious uveitis burden on quality of life and work impairment assessed through different psychometric questionnaires. Eur J Ophthalmol. 2022; 32/4, pp 2282-2290 Epub ahead of print. 2021 Aug 16:11206721211034649. doi: 10.1177/11206721211034649. PMID: 34399603.
  13. Scimone C, Donato L, Alibrandi S, Vadalà M, Giglia G, Sidoti A, D’Angelo R. N-retinylidene-N-retinylethanolamine adduct induces expression of chronic inflammation cytokines in retinal pigment epithelium cells. Exp Eye Res. 2021 May 29;209:108641. doi: 10.1016/j.exer.2021.108641. Epub ahead of print. PMID: 34058230.
  14. Midena E, Varano M, Pilotto E, Staurenghi G, Camparini M, Pece A, Battaglia Parodi M, Vadalà M, Donati S, Frizziero L, Fiorencis A, Marini MG, Reale L. Real-life patient journey in neovascular age-related macular degeneration: a narrative medicine analysis in the Italian setting. Eye (Lond). 2022 Jan;36(1):182-192. doi: 10.1038/s41433-021-01470-9. Epub 2021 Mar 5. PMID: 33674730; PMCID: PMC8727581.
  15. Mulè G, Vadalà M, Sinatra N, Mancia E, Sorce A, Geraci G, Carollo C, Montalbano K, Castellucci M, Guarrasi G, Cillino S, Cottone S. Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients. J Clin Hypertens (Greenwich). 2021 May;23(5):1030-1038. doi: 10.1111/jch.14196. Epub 2021 Jan 25. PMID: 33492773; PMCID: PMC8678803.
  16. Antona V, Scalia F, Giorgio E, Radio FC, Brusco A, Oliveri M, Corsello G, Lo Celso F, Vadalà M, de Macario EC, Macario AJL, Cappello F, Giuffrè M. A novel cct5 missense variant associated with early onset motor neuropathy. International Journal of Molecular Sciences 2020, 21 (20), art. no. 7631, pp. 1-12. DOI: 10.3390/ijms21207631
  17. Mulè G, Sinatra N, Vario MG,Vadalà M, Cottone S. The renal dangers of an increased cardio-ankle vascular index. Am J Hypertension 2020 Nov 3:33(11): 993-995. Doi:10.1093/ajh/hpaa110. PMID: 32629473,
  18. Vadalà M, Sunseri Trapani V, Guarrasi G, Ventura N, Castellucci M, Cillino S. A Real-World study of Dexamethasone Implant in treatment-naïve patients with diabetic macular edema: efficacy and correlation between inflammatory biomarkers and treatment outcome. Clin Ophthalmol. 2020; 14: 2657–2665. Published online 2020 Sep 15. doi: 10.2147/OPTH.S257775
  19. Bonfiglio V, Reibaldi M, Macchi I, Fallico M, Pizzo C, Patanè C, Russo A, Longo A, Pizzo A, Cillino G, Cillino S, Vadalà M, Rinaldi M, Rejdak R, Nowomiejska K, Toro MD, Avitabile T, Ortisi E. Preoperative, Intraoperative and Postoperative Corticosteroid Use as an Adjunctive Treatment for Rhegmatogenous Retinal Detachment. J Clin Med. 2020 May; 9(5): 1556. Published online 2020 May 21. doi: 10.3390/jcm9051556
  20. Geraci G, Zammuto M, Vadalà M, Mattina A, Castellucci M, Guarrasi G, Nardi E, Maida C, Zanoli L, Cillino S, Cottone S, Mulè G. Choroidal thickness is associated with renal hemodynamics in essential hypertension. J Clin Hypertens (Greenwich). 2020 Feb;22(2):245-253. doi: 10.1111/jch.13777. Epub 2020 Jan 15. PMID: 31945274.
  21. Cillino S, Castellucci M, Cillino G, Sunseri Trapani V, Novara C, Di Pace F, Vadalà M, Bonfiglio V, Casuccio A. Infracyanine Green vs. Brilliant Blue G in Inverted Flap Surgery for Large Macular Holes: A Long-Term Swept-Source OCT Analysis. Medicina (Kaunas) 2020 Jan; 56(1): 43. Published online 2020 Jan 20. doi: 10.3390/medicina56010043 PMID:31968622. 
  22. Gagliardo C, Radellini S, Morreale Bubella R, Falanga G, Richiusa P, Vadalà M, Ciresi A, Midiri M, Giordano C. Lacrimal gland herniation in Graves ophthalmopathy: a simple and useful MRI biomarker of disease activity. Eur Radiol. 2020 Apr;30(4):2138-2141. doi: 10.1007/s00330-019-06570-5. Epub 2020 Jan 17. PMID: 31953667.
  23. Scondotto G, Sultana J, Ientile V, Ingrasciotta Y, Fontana A, Copetti M, Mirabelli E, Trombetta CJ, Rapisarda C, Reibaldi M, Avitabile T, Longo A, Ibanez Toro P, Vadalà M, Cillino S, Virgili G, Gini R, Leoni O, Pollina Addario SW, Cananzi P, La Cavera C, Puzo MR, De Sarro G, De Francesco A, Trifirò G. How Have Intravitreal Anti-VEGF and Dexamethasone Implant Been Used in Italy? A Multiregional, Population-Based Study in the Years 2010–2016. Biomed Res Int. 2020 Jan 11;2020: 7582763. doi: 10.1155/2020/7582763. PMID:31998798; PMCID: PMC6977336
  24. Fallico M, Avitabile T, Castellino N, Longo A, Russo A, Bonfiglio V, Parisi F, Furino C, Panozzo C, Scorcia V, Carnevali A, Bandello F, Battaglia Parodi M, Cennamo G, Cillino S, Vadalà M, Sunseri Trapani V, Cagini C, Fiore T, Lupidi T, Parravano MC, Varano M, Giorno P, Boscia F, Giancipoli E, Eandi C, Le Mer Y, Reibaldi M. Intravitreal dexamethasone implant one month before versus concomitant with cataract surgery in patients with diabetic macular edema: the DEXCAT study. Acta Ophthalmol 2021, feb; 99(1):e74-e80, doi:10.1111/aos.14516. Epub 2020 Jun 26 PMID:32588978.
  25. Vadalà M, Davì C, Ingrassia Strano G, Giuffrida E, Scrivo B, Ventura N, Castellucci M, Cillino S, Cammà C, Cappello M. The ocular manifestations in IBD screening (OMIS) questionnaire: pilot study on detection of ocular involvement in inflammatory bowel diseases. Int Ophthalmol. 2020 Oct;40(10):2569-2576. doi: 10.1007/s10792-020-01437-x. Epub 2020 Jun 7. PMID: 32507951.
  26. Mulè G, Vadalà M, Guarrasi G, Geraci G, Montalbano K, Calandra I, Carollo C, Mancia E, Cillino S, Cottone S. Relationship between blood pressure values and choroidal thicknesses in hypertensive patients. High blood press cardiovasc prev 2019 https://doi.org/10.1007/s40292-019-00340-6, pagina 29-30. Selected Abstracts from XXXVI National Congress of the Italian Society of Hypertension (SIIA), Rome, 26–28 September 2019
  27. Vadalà M, Castellucci M, Guarrasi G, Terrasi M, La Blasca T, Mulè G. Retinal and choroidal vasculature changes associated with chronic kidney disease. Graefes Arch Clin Exp Ophthalmol. 2019 Aug;257(8):1687-1698. doi: 10.1007/s00417-019-04358-3. Epub 2019 May 30. PMID: 31147842.
  28. Mulè G, Vadalà M, La Blasca T, Gaetani R, Virone G, Guarneri M, Castellucci M, Guarrasi G, Terrasi M, Cottone S. Association between early-stage chronic kidney disease and reduced choroidal thickness in essential hypertensive patients. Hypertens Res. 2019 Jul;42(7):990-1000. doi: 10.1038/s41440-018-0195-1. Epub 2019 Jan 10. PMID: 30631159.
  29. Felden J, Baumann B, Ali M, Audo I, Ayuso C, Bocquet B, Casteels I, Garcia‐Sandoval B, Jacobson SG, Jurklies B, Kellner U, Kessel L, Lorenz B, McKibbin M, Meunier I, deRavel T, Rosenberg T, Rüther K, Vadalà M, Wissinger W, Stingl K, Kohl S. Mutation spectrum and clinical investigation of achromatopsia patients with mutations in the GNAT2 gene Human Mutation. 2019 May 6;1–11. doi: 10.1002/humu.23768
  30. Mulè G, Vadalà M, Geraci G, Cottone S. Retinal vascular imaging in cardiovascular medicine: new tools for an old examination. Atherosclerosis. 2018 Jan;268:188-190. doi: 10.1016/j.atherosclerosis.2017.11.001. Epub 2017 Nov 7.
  31. Piscitello S, Vadalà M. Postoperative endophthalmitis incidence after intravitreal therapy: a comparison of two different preoperative antibiotic prophylaxis. Int Ophthalmol. 2017 Aug;37(4):787-794. doi: 10.1007/s10792-016-0307-3. Epub 2016 Sep 1.
  32. Neuillé M, Malaichamy S, Vadalà M, Michiels C, Condroyer C, Sachidanandam R, Srilekha S, Arokiasamy T, Letexier M, Démontant V, Sahel JA, Sen P, Audo I, Soumittra N, Zeitz C. Next-generation sequencing confirms the implication of SLC24A1 in autosomal-recessive congenital stationary night blindness (CSNB). Clin Genet. 2016 Jun;89(6):690-699. doi: 10.1111/cge.12746. Epub 2016 Mar 4.
  33. Pece A, Milani P, Monteleone C, Trombetta CJ, De Crecchio G, Fasolino G, Matranga D, Cillino S, Vadalà M. A randomized trial of intravitreal bevacizumab vs ranibizumab for myopic CNV. Graefes Arch Clin Exp Ophthalmol. Graefes Arch Clin Exp Ophthalmol. 2015 Nov;253(11):1867-72. doi: 10.1007/s00417-014-2886-x. Epub 2014 Dec 13.

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